Life shortening in BALB/c mice following brief, protracted, or fractionated exposures to neutrons
The effects of acute, protracted, or fractionated exposures to fission neutrons on survival times of female BALB/c mice were examined and compared. Mice were given single, brief exposures or exposures given in equal fractions at either 1- or 30-day intervals to doses of 0, 2.5, 5, 10, 20, 50, and 200 rad at the Health Physics Research Reactor (HPRR) or protracted exposures at rates ranging from 0.1 to 10 rad/day using a moderated /sup 252/Cf source to doses of 0, 2.5, 5, 10, 20, and 40 rad. After single or fractionated exposures the extent of life shortening increased rapidly over the 0 to 50 rad range and then began the plateau. No simple model adequately described the dose response over this entire dose range. No increase in effectiveness after fractionation or protraction was observed for neutron-induced life shortening at doses below 50 rad, while at 50 and 200 rad an increase in effectiveness was observed in this and in previous studies. These data were interpreted to suggest that in the dose range below 20 to 40 rad the dose-effect curve for life shortening may be linear and begins to flatten at higher doses rather than continuously bending at low doses.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5010238
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACUTE EXPOSURE
ACUTE IRRADIATION
AIR COOLED REACTORS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
DATA
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EPITHERMAL REACTORS
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
FAST REACTORS
FERMIONS
FISSION NEUTRONS
FRACTIONATED IRRADIATION
GAS COOLED REACTORS
HADRONS
HEAVY NUCLEI
HPRR REACTOR
INFORMATION
IRRADIATION
ISOTOPES
LIFE SPAN
MAMMALS
MATHEMATICAL MODELS
MICE
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
PULSED REACTORS
RADIATION EFFECTS
RADIOISOTOPES
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES