Distribution of tungstate in pregnant mice and effects on embryonic cells in vitro

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80124-4· OSTI ID:5002167

Wide, M; Danielsson, B R.G.; Dencker, L

Whole-body autoradiography and impulse counting experiments were used to study the distribution and retention of radioactivity in the pregnant mouse after administration of (/sup 185/W)tungstate. A rapid uptake was found in a number of tissues - skeleton, red pulp of the spleen, adrenal, liver, thyroid, pituitary, and ovary - and in the intestine and kidneys, through which it was rapidly excreted. /sup 185/W was also readily transported from mother to fetus, although more in late than in early gestation. The largest metal retention was found in the maternal skeleton, kidneys, and spleen and in visceral yolk sac epithelium and the skeleton of the fetus. Furthermore, in vitro cytotoxicity experiments showed inhibition by tungstate of cartilage production in limb bud mesenchymal cultures at concentrations similar to those found in vivo.

• Research Organization: Uppsala Univ., Sweden
• OSTI ID: 5002167
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVITY LEVELS
ADRENAL GLANDS
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CELL DIFFERENTIATION
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
EMBRYONIC CELLS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FEMALE GENITALS
FETUSES
GLANDS
GONADS
HEAVY NUCLEI
INFORMATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ORGANS
OVARIES
PITUITARY GLAND
PRENATAL EXPOSURE
RADIOISOTOPES
RETENTION
RODENTS
SKELETON
SPLEEN
THYROID
TISSUE DISTRIBUTION
TOXICITY
TUNGSTATES
TUNGSTEN 185
TUNGSTEN ISOTOPES
UPTAKE
VERTEBRATES