Oxygen-derived species: Their relation to human disease and environmental stress
Journal Article
·
· Environmental Health Perspectives
- Univ. of California-Davis Medical Center, Sacramento, CA (United States)
Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes. Antioxidant defenses protect against them, but these defenses are not completely adequate, and systems that repair damage by ROS are also necessary. Mild oxidative stress often induces antioxidant defense enzymes, but severe stress can cause oxidative damage to lipids, proteins, and DNA within cells, leading to such events as DNA strand breakage and disruption of calcium ion metabolism. Oxidative stress can result from exposure to toxic agents, and by the process of tissue injury itself. Ozone, oxides of nitrogen, and cigarette smoke can cause oxidative damage; but the molecular targets that they damage may not be the same. 88 refs., 1 fig., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 494238
- Report Number(s):
- CONF-9308288--; CNN: Grant HL47628; Grant RR-00169; Grant ES-00628
- Journal Information:
- Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.10 Vol. 102; ISSN 0091-6765; ISSN EVHPAZ
- Country of Publication:
- United States
- Language:
- English
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