Oxidative stress and oxidative damage in chemical carcinogenesis
Journal Article
·
· Toxicology and Applied Pharmacology
Reactive oxygen species (ROS) are induced through a variety of endogenous and exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by ROS may result in oxidative stress and oxidative damage to the cell. This resulting oxidative stress can damage critical cellular macromolecules and/or modulate gene expression pathways. Cancer induction by chemical and physical agents involves a multi-step process. This process includes multiple molecular and cellular events to transform a normal cell to a malignant neoplastic cell. Oxidative damage resulting from ROS generation can participate in all stages of the cancer process. An association of ROS generation and human cancer induction has been shown. It appears that oxidative stress may both cause as well as modify the cancer process. Recently association between polymorphisms in oxidative DNA repair genes and antioxidant genes (single nucleotide polymorphisms) and human cancer susceptibility has been shown.
- OSTI ID:
- 21587794
- Journal Information:
- Toxicology and Applied Pharmacology, Journal Name: Toxicology and Applied Pharmacology Journal Issue: 2 Vol. 254; ISSN TXAPA9; ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Redox cycling of endogenous copper by ferulic acid leads to cellular DNA breakage and consequent cell death: A putative cancer chemotherapy mechanism
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
Mechanisms of cadmium carcinogenesis
Journal Article
·
Mon Nov 30 23:00:00 EST 2015
· Toxicology and Applied Pharmacology
·
OSTI ID:22687831
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
Journal Article
·
Thu Apr 01 00:00:00 EDT 2010
· Toxicology and Applied Pharmacology
·
OSTI ID:21344909
Mechanisms of cadmium carcinogenesis
Journal Article
·
Sat Aug 01 00:00:00 EDT 2009
· Toxicology and Applied Pharmacology
·
OSTI ID:21272615