Selenium and vitamin E deficiencies do not enhance lung inflammation from cigarette smoke in the hamster

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5893816

Niewoehner, D E; Peterson, F J; Hoidal, J R

The early lung inflammatory response to cigarette smoke may be oxidant-mediated. We fed Syrian hamsters a diet deficient in selenium and vitamin E to determine whether impairment of the lung's antioxidant defenses might worsen inflammation induced by cigarette smoke. After 8 wk, cigarette-smoke-exposed animals had characteristic inflammatory lesions in the distal airways. Increased numbers of phagocytes, predominantly macrophages, were recovered by lavage and these cells exhibited enhanced oxidative metabolism. Animals fed the deficient diet had profound depletions of selenium and vitamin E, but no alterations in the histologic appearance of smoke-induced inflammatory lesions, in the numbers of phagocytes recruited, or in the oxidative metabolism of these phagocytes. These results suggest that selenium and vitamin E are unimportant in protecting against cigarette-smoke-induced lung injury.

• Research Organization: Pulmonary Section, Veterans Administration Medical Center, Minneapolis, Minnesota
• OSTI ID: 5893816
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 127:2; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
DIET
DISPERSIONS
ELEMENTS
HAMSTERS
INJURIES
LUNGS
MAMMALS
ORGANS
RESIDUES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SELENIUM
SEMIMETALS
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES
VITAMIN E
VITAMINS