PROGRESSIVE ALTERATION OF SERUM PROTEINS IN RATS SEVERAL MONTHS AFTER AN ACUTE OR PROTRACTED IRRADIATION

Conference · Sat Jun 15 04:00:00 EDT 1963

OSTI ID:4878065

Ghys, R.; Reuter, A.

Delayed changes of the serum proteins in male Sprague Dawley rats that survived the acute radiation syndrome were investigated. Doses of Co/sup 60/ gamma ranging from LD/sub O/ to LD/sub 50/ were given to rats six to eight weeks of age. Paper electrophoreses and microdosage of proteins by the buiret method were performed on plasma proteins for 206 rats: 29 with acute irradiation; 73 chronic irradiation; 44 acute irradiation following cold acclimatization; and 80 normal animals. No significant variations in the total serum proteins were found in andy one group. Alpha globulins were found to be slightly above normal in some irradiated rats, but there was no significant variation in the BETA globulin fraction. Gamma globulins showed a marked and consistent increase following irradiation. Thus for observed protein chandges in irradiated rats have not proven to be dose dependent. It is suggested that the changes may provide a link between early irradiation syndrome and late effects. (H.M.G.)

• Research Organization: Laval Univ., Quebec (Canada). Radiobiology Lab.
• NSA Number: NSA-18-003582
• OSTI ID: 4878065
• Report Number(s): CONF-294-1; AED-Conf--63-145-1
• Country of Publication: Canada
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD SERUM
COBALT 60
CONFERENCE
ELECTROPHORESIS
GAMMA RADIATION
GLOBULINS
PROTEINS
QUALITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RATS
TRACE AMOUNTS
VARIATIONS