Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5
- National Institutes of Health, Bethesda, MD (United States); and others
Lhx5, the mouse ortholog of the Xenopus Xlim-5, is a LIM/homeobox gene expressed in the central nervous system during both embryonic development and adulthood. During development its domain of expression is mainly localized at the most anterior portion of the neural tube, and it precedes the morphological differentiation of the forebrain; for this reason we believe that Lhx5 could play an important role in forebrain patterning. Here we present the structural organization and the chromosomal localization of the Lhx5 gene. The gene is composed of five exons spanning more than 10 kb of genomic sequence. The first and second LIM domains are encoded by the first and second exon, while the codons of the homeobox are split between the third and the fourth exons. The structure of Lhx5 is similar to that of other LIM/homeodomain proteins, Lxh1/lim1 and Lhx3/lim3, but differs from that of other LIM genes, such as mec3 and LMO1/Rbtn1, in which the codons for the LIM domains are interrupted by introns. We have mapped Lhx5 to the central region of mouse chromosome 5. 38 refs., 4 figs.
- OSTI ID:
- 486308
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32. 1
Cloning of rat homeobox genes
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
Journal Article
·
Sun May 15 00:00:00 EDT 1994
· Genomics; (United States)
·
OSTI ID:6872520
Cloning of rat homeobox genes
Journal Article
·
Sat Oct 01 00:00:00 EDT 1994
· Biochemical Genetics
·
OSTI ID:83458
Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
Journal Article
·
Wed Sep 03 00:00:00 EDT 2008
· EMBO J.
·
OSTI ID:1006779