LATE MANIFESTATIONS OF IONIZING RADIATION IN THE DOG

Technical Report · Wed May 31 04:00:00 EDT 1961

OSTI ID:4843732

Michaelson, S M; Quinlan, W J; Hansen, Jr, C L; Neidlinger, R L; Odland, L T; Howland, J W

Beagles of known age were bilaterally exposed to 1000 Kvp x rays to the whole-body or upper half of the body. One year after exposure, whole-body exposed animals appear clinically normal. Total leukocyte counts have returned to within 75% of the pre-exposure levels, with more rapid recovery among higher dose exposures. Clinical chemistries have remained within normal limits. Body weight is slightly increased in comparison with the controls. There is no evidence of cataract formation. No deaths have occurred in the 2 to 12 month period since irradiation. Upper body exposed animals show variable changes. Below 1500 r, weight is comparable to controls, total leukocyte counts are slightly below pre-exposure levels, and clinical chemistries have remained normal. There is no evidence of lenticular changes. General physi cal appearance is normal and no deaths have occurred between 2 and 12 months since irradiation. Survivors from 1500 and 1750 r groups show decreased weight. Total leckocyte counts have returned to pre-exposure levels. Residual corneal vascular opacification or posterior polar cataracts are evident in most of the 1500 and 1750 r survivors. In the 6 to 12 month period since irradiation, most of the 1500 and 1750 r survivors have developed pulmonary difficulty with dyspnea, oxygen desaturation, and terminal pulmonary fibrosis leading to death. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-15-027488
• OSTI ID: 4843732
• Report Number(s): UR-595
• Country of Publication: United States
• Language: English

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD VESSELS
BODY
DISEASES
DOGS
EYES
LEUCOCYTES
LUNGS
QUANTITY RATIO
RADIATION DOSES
RECOVERY
WEIGHT
X RADIATION