CARDIOPULMONARY CHANGES IN THE DOG FOLLOWING EXPOSURE TO X-RAYS
Technical Report
·
OSTI ID:4843072
Radiation pneumonitis and pulmonary fibrosis, after therapeutic irradiation over the chest in man and experimentally induced in dogs are described. Pulmonary function in these cases was not extensively investigated. Irradiation of the upper body of beagles with 1000 kvp x rays results in early pulmonary dysfunction. Defective thermal regulation is evident when these animals are subjected to increased environmental temperature or microwave heating. Tachypnea at rest with marked hyperventilation on exercise is noted as early as 7 months following 1750 r MTD (midline tissue dose) and 9 months afier 1500 r MTD. As the condition progresses, artenial oxygen saturation is reduced. Death occurs 10 months after 1750 r and 11 months after 1500 r MTD. Necropsy reveals cardiac and pulmonary lesions. (auth)
- Research Organization:
- Rochester, N. Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-15-028993
- OSTI ID:
- 4843072
- Report Number(s):
- UR-596
- Country of Publication:
- United States
- Language:
- English
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