THE BIOLOGICAL EFFECTS OF UPPER BODY X-IRRADIATION OF BEAGLES
Technical Report
·
OSTI ID:4109699
Results are reported from a study designed to delineate the biological effects of upper body (head and thorax) irradiation of beagles exposed to 1000 kvp x rays. Ninety-five pure-bred adult beagles of both sexes were used. Groups of ten dogs were exposed to 800, 1000, 1500, 1750, and 2000 r midline tissue dose. In addition, a control group of ten dogs was sham irradiated under similar conditions to that of the 1500 r group. The remainder of the animals were used for whole-body irradiation. The clinical course, including physical and neurological changes from the preirradiation pattern, is described; the hematological and pathological findings also are dsscribed. The median lethal dose (LD-50/30) for upper-body irradiation was determined to be 1775 r as compared to 250 r for wholebody irradiation. Lethality is considered to be associated with damage to several organ systems, making the animal vulnerable to bacterial invasion. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-15-003869
- OSTI ID:
- 4109699
- Report Number(s):
- UR-580
- Country of Publication:
- United States
- Language:
- English
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