THE EFFECT OF X-IRRADIATION ON EMBRYONIC HEMATOPOIETIC TISSUE. Final Report, January 15, 1958 to January 14, 1961
A total of 581 guinea pigs was used to investigate the effects of x rays on developing hematopoietic tissues. Each pregnant female was anesthetized with sodium pentcbarbital and a laparotomy was performed. The embryos in one uterine horn were irradiated once. The embryos in the opposite uterine horn served as non-irradiated controls After irradiation, all embryos were sacrificed and the hematopoietic tissues were studied. Hematopoiesis in the yolk sac of irradiated embryos did not differ from that in the control embryos regardless of the age at the time of the irradiation. Differences in hematopoiesis in the liver, spleen, and thymus were not found between control embryo and 13-day embryos irradiated with 27, 52, or 78 r, or 15-day embryos irradiated with 50 r, or 16-day embryos irradiated with 100 r. Mild to severe fibrosis of the spleen was found in young animals irradiated with 250 or 300 r as 27-day embryos, and sacrificed at 11, 27, and 28 months after irradiation. The lymphocytes of the thymus were the most sensitive hematopoietic cells. The response of blood cell precursors in the liver was generally the same as in the spleen. After irradiation, the hematopoietic cells in these organs showed moderate karyorrhexis. The mesenchymal cells of all hematopoietic tissues were more radioresistant than were the blood cell precursors. In most respects, the effect of irradiation on the embryonic hema topoietic tissues and cells was similar to that described in post- natal hematopoietic tissues and cells. (auth)
- Research Organization:
- Colorado State Univ., Fort Collins. Coll. of Veterinary Medicine
- NSA Number:
- NSA-15-028990
- OSTI ID:
- 4843138
- Report Number(s):
- TID-13393
- Country of Publication:
- United States
- Language:
- English
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