PATHOLOGIC EFFECTS OF INGESTED STRONTIUM-90 IN RATS AND MONKEYS

Technical Report · Mon Jun 12 04:00:00 EDT 1961

OSTI ID:4843137

Casarett, G W; Tuttle, L W; Baxter, R C

Seven young adult Rhesus monkeys were given Sr/sup 90/ solution orally. Of three which imbibed 500 mu c, the first died in 35 months of radiation effects on hemopoietic tissues and parasitism, with a retained body burden of 34 mu c, having received about 4500 rads to the skeleton. The second died of monocytic leakemia (variant of lymphatic leukemia) in 48 months, with a retained bcdy burden of 45 mu c and a skeletal dose of 4300 rads. The third monkey is alive and well after 80 months, with a body burden of 22 mu c and a skeletal dose to date of about 2000 rads. Four of the monkeys imbibed 1000 mu c Sr/sup 90/. The first died of pancytopenia in 4 months, with a retained body burden of 200 mu c and a skeletal dose of 4500 rads. The second died of pancytopenia and parasitism in 18 months, with 116 mu c retained and a skeletal dose of 9100 rads. The third died of chondrosarcoma after 36 months, with a retained body burden of 76 mu c and a skeletal dose of 9500 rads. The fourth died after 45 months of osteosarcoma, with a body burden of 33 mu c and a skeletal dose of 4700 rads. Rats 425 days old given 330 mu c Sr/sup 90/ orally in 10 days showed slight damage of bone marrow and premature involution of the cartilage plate in zones of endochondral ossification. Five months after the last dose these rats had retained 1 mu c in the skeleton. The average accumulated dose to the skeleton at this time was approximately 300 to 600 rads in male and female rats, respectively. Rats 346 days old given 650 mu c in 10 days showed somewhat greater damage of marrow and of the cartilage plate, and increased incidence of softtissue malignancies, including leukemia and facial skin carcinomas. These rats retained 2 mu c at 5 months after the last dose and had accumulated approximately 700 to 1100 rads. Rats 117 days old given 790 mu c in 30 days showed marked damage of marrow and bone growth centers, high incidence of osteosarcoma (27.5%), increase in incidence of certain soft-tissue malignancies, including leukemia (6.25%) and facial skin carcinoma (11.25%), and life span shortening (34%). The skeletons of these rats had received radiation doses of from 3700 to 5200 rads and retained 11 mu c at 5 months after ingestion. Rats 40 days old given 464 mu c in 10 days showed severe damage of marrow and bone growth centers, high incidence of osteosarcoma (17.5%), and marked life shortening (80%). These rats retained 33 mu c five months after dosing and skeletal doses at this time were estimated to have been 19000 to 25000 rads. (auth)

• Research Organization: Rochester, N. Y. Univ. Atomic Energy Project
• NSA Number: NSA-15-028994
• OSTI ID: 4843137
• Report Number(s): UR-597
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
BONES
CANCER
LEUKEMIA
LIFETIME
MONKEYS
PARASITES
RADIATION DOSES
RADIATION INJURIES
RATS
SEX
SKIN
STRONTIUM 90
TISSUES
TUMORS