Single inhalation exposure to 90SrCl2 in the beagle dog: hematological effects

Journal Article · Fri May 01 04:00:00 EDT 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576904· OSTI ID:6351547

Gillett, N A; Muggenburg, B A; Boecker, B B; Hahn, F F; Seiler, F A; Rebar, A H; Jones, R K; McClellan, R O

The toxicity of /sup 90/Sr administered by the inhalation route was studied in young adult Beagle dogs exposed once to aerosols containing /sup 90/SrCl/sub 2/. Due to its relatively soluble chemical form, /sup 90/Sr was rapidly translocated from lung to bone where a substantial portion was retained for a long period of time. This resulted in only a brief radiation exposure of the respiratory tract and a protracted exposure of the skeleton. The long-term retained burdens ranged from 0.037 to 4.4 MBq /sup 90/Sr/kg body wt. Dogs were subsequently observed throughout their life span. Six dogs with long-term retained burdens of 1.7 to 4.1 MBq /sup 90/Sr/kg died at less than 32 days after exposure from radiation-induced bone marrow hypoplasia. Review of hematological parameters of all dogs showed a similar, consistent, and dose-related pancytopenia in those animals having a long-term retained burden of greater than 0.37 MBq /sup 90/Sr/kg. Thrombocytopenia and neutropenia persisted in all exposed dogs through 1000 days after exposure. For reference purposes, a burden of 0.37 MBq /sup 90/Sr/kg is calculated to deliver an average radiation dose to the skeleton over 30, 100, and 1000 days after intake of 1.0, 2.8, and 17 Gy, respectively. The hematologic changes were similar to those seen in people exposed to high doses of whole-body external radiation.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
• OSTI ID: 6351547
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY BURDEN
BONE MARROW
COLLOIDS
DISEASES
DISPERSIONS
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
EVEN-EVEN NUCLEI
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
MAMMALS
NUCLEI
ORGANS
RADIATION DOSES
RADIOACTIVE AEROSOLS
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RETENTION
SKELETON
SOLS
STRONTIUM 90
STRONTIUM ISOTOPES
TISSUES
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES