THE EFFECTS OF CARDIAC IRRADIATION UPON THE NORMAL CANINE HEART

Journal Article · Sun Oct 01 04:00:00 EDT 1961 · Am. J. Roentgenol., Radium Therapy Nuclear Med.

OSTI ID:4843128

Senderoff, E; Kaneko, M; Beck, A R; Baronofsky, I D

Ligation of the anterior descending coronary artery was performed on 66 dogs following varying doses of cardiac irradiation at varying intervals of time. A pathologic analysis of the hearts by means of injection and corrosion studies, and gross and microscopic examination was carried out. Thirty control dogs, similarly ligated but not irradiated, were studied in the same manner. Nineteen irradiated animals, dying at varying intervals during and after radiation therapy (but prior to coronary ligation), were also studied. The irradiated animals presented functioning intercoronary anastomotic channels at the time of coronary ligation. A spared area of normal muscle was seen in the subepicardium overlying the area of infarction in the irradiated hearts, but was not observed in the nonirradiated control hearts. Irradiated hearts healed faster than equivalent control hearts following myocardial infarction, as healing could occur from the spared area of normal muscle. The effects of varying doses of cardiac irradiation upon the heart, lungs, bone marrow, hemogram, and mediastinal tissues were studied up to one year following irradiation. Evidence of focal radiation induced pleural and marrow changes directly under the field of irradiation was observed at some doses. The significance of these findings is discussed. (auth)

• Research Organization: Mount Sinai Hospital, New York
• NSA Number: NSA-15-029009
• OSTI ID: 4843128
• Journal Information: Am. J. Roentgenol., Radium Therapy Nuclear Med., Journal Name: Am. J. Roentgenol., Radium Therapy Nuclear Med. Vol. Vol: 86
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD VESSELS
BODY
BONE MARROW
DOGS
HEART
IRRADIATION
LUNGS
MUSCLES
RADIATION DOSES