FURTHER STUDIES OF THE EFFECTS OF CARDIAC IRRADIATION UPON MYOCARDIAL VASCULARITY

Journal Article · Wed Mar 01 04:00:00 EST 1961 · Surgery (U.S.)

OSTI ID:4714929

Senderoff, E; Beck, A R; Baronofsky, I D

Experiments in dogs were undertaken to test the ability of cardiac irradiation to induce coronary arterial collateral circulation. Dogs received 2000 r cardiac irradiation and were subjected to ligation of the left circumflex coronary artery at its origin 7 days after irradiation. Only 8% of the nonirradiated dogs survived 48 hr or longer after the ligation in contrast to 40% of the irradiated dogs. Irradiated dogs also exhibited better electrocardiograms, greater intercoronary flow, and more vascular hearts as determined by corrosion studies. Electrocardiograms taken 2 to 7 hr after ligation in nonirradiated dog hearts, which did not fibrillate, showed the presence of severe infarctions with marked S-T elevations, also ventricular tachycardia, flutter with varying degrees of block or complete heart block. The electrocardiograms of irradiated animals also showed evidence of infarction but the S-T segments were not so sharply elevated. The results show that cardiac irradiation induced a dilatation of the intercoronary anastomotic bed, thus accounting for increased survival rate and retrograde blood flow regardless of which portion of the heart vasculature is ligated. (TCO)

• Research Organization: Mt. Sinai Hospital, New York
• NSA Number: NSA-17-021568
• OSTI ID: 4714929
• Journal Information: Surgery (U.S.), Journal Name: Surgery (U.S.) Vol. Vol: 49; ISSN SURGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
CORONARIES
DOGS
HEART
IRRADIATION
MEDICINE
PHYSIOLOGY
RADIATION DOSES
SURGERY
SURVIVAL TIME