Effect of nitroglycerin on myocardial collateral conductance in awake dogs

Journal Article · Fri Apr 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:7014728

Brazzamano, S; Rembert, J C; Greenfield, Jr, J C ^[1]

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1. Duke Medical Center, Durham, NC (USA)

Conductance of the coronary collateral circulation during the course of two abrupt circumflex coronary occlusions was measured in awake dogs {approximately} 2 wk after collateral vessels were stimulated to develop. The pressure gradient from the central aorta to the distal circumflex coronary artery was measured, and myocardial blood flow was determined by 9-{mu}m radioactive microspheres at 30 s and 4 min after coronary occlusions. Collateral conductance was calculated as mean collateral blood flow divided by the mean aorta-coronary pressure gradient. Before nitroglycerin, collateral conductance increased in all eight dogs from 30 s to 4 min. After nitroglycerin administration, the conductance at 30 s increased from the prenitroglycerin control value to 0.014 {+-} 0.012 ml{center dot}min{sup {minus}1}{center dot}g{sup {minus}1}{center dot}mmHg{sup {minus}1}. The mean change in conductance from 30 s to 4 min postnitroglycerin was significantly less than during prenitroglycerin. These data indicate that an increase in conductance during coronary occlusion occurs even in the immature collateral circulation. This effect presumably takes place in the arterial smooth muscle at the origin of the collateral vasculature.

• OSTI ID: 7014728
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:4; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
CHEMICAL EXPLOSIVES
CHROMIUM 51
CHROMIUM ISOTOPES
CORONARIES
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
EXPLOSIVES
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NIOBIUM 95
NIOBIUM ISOTOPES
NITRIC ACID ESTERS
NITROGLYCERIN
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PERFUSED TISSUES
RADIOASSAY
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUTHENIUM 103
RUTHENIUM ISOTOPES
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
TIN 113
TIN ISOTOPES
TISSUES
VASODILATION
VERTEBRATES