Effects of preoperative irradiation on primary tracheal anastomosis
Conference
·
· Ann. Thorac. Surg.; (United States)
OSTI ID:7133113
Preoperative radiotherapy was used in the management of selected patients with cancer of the lung or trachea who might subsequently require segmental resection of bronchus or trachea and reconstruction by primary anastomosis. This study was designed to determine the effects of varying dosages of preoperative irradiation on anastomotic healing. Two rings were resected from the cervical trachea of 20 dogs following irradiation with varying doses of cesium. There were no important adverse effects on healing of the trachea or adjacent organs in dogs receiving up to 3,500 rads. All dogs receiving a higher dose than this developed some anastomotic stenosis, which was severe in 6 of 8 animals. Similar adverse effects were observed in 2 patients managed by preoperative radiotherapy (4,000 rads in three weeks) and tracheal resection with primary anastomosis.
- Research Organization:
- Univ. of Toronto
- OSTI ID:
- 7133113
- Conference Information:
- Journal Name: Ann. Thorac. Surg.; (United States) Journal Volume: 20:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOGS
DOSES
MALFORMATIONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
PATHOLOGICAL CHANGES
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TRACHEA
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOGS
DOSES
MALFORMATIONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
PATHOLOGICAL CHANGES
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TRACHEA
VERTEBRATES