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U.S. Department of Energy
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ON THE NUTRITIVE VALUE OF THE MAJOR NUTRIENTS OF IRRADIATED FOODS AND APPRAISAL OF THE TOXICITY OF IRRADIATED FOODS. Progress Report No. 19, September 1, 1960-March 1, 1961

Technical Report ·
OSTI ID:4843105
Estradiol injected into male rats kept on a vitamin K-free diet was effective in lowering the plasma prothrombin time to normal values in about 6 hours. This vitamin K-like activity was observed even at a dosage of 20 mu g/ rat. Conversely, testosterone administration (1 mg/rat) to female rats increased significantly the plasma prothrombin time as compared to the untreated control. Unlike the effects observed with rats, male and female chicks were equally susceptible to dietary vitamin K deficiency, and estradiol administration, even at a dose of 1 mg/chick, did not alleviate the hypoprothrombinemia. In rats with vitamin K deficiency, as indicated by the prothrombin time, no clear difference in the efficiency of oxidative phosphorylation between mitochondria isolated from normal and K-deficient animals could be detected. (M.C.G.)
Research Organization:
Illinois. Univ., Urbana
NSA Number:
NSA-15-028889
OSTI ID:
4843105
Report Number(s):
NP-10519
Country of Publication:
United States
Language:
English