ON THE NUTRITIVE VALUE OF THE MAJOR NUTRIENTS OF IRRADIATED FOODS AND APPRAISAL OF THE TOXICITY OF IRRADIATED FOODS. Progress Report No. 18 for Period March 16, 1960-September 1, 1960
Feeding of irradiated beef or vitamin K-low synthetic diets results in hypoprothrombinemia and hemorrhagic deaths of growing male rats. The female rat is markedly resistant to K deficiency. The possibility of estrogen involvement in the role of K in some unknown manner is worthy of further study. Normal reproduction was obtained in female rats maintained on synthetic K-low diets or irradiated beef diets and mated with normal males. The sur vival of the pups was, however, poor. None of them died of hemorrhage, and good survival has been obtained on rats fed irradiated beef diets with supplements of K only when they are maintained in an isolated room free from respiratory disease. Although it was found that the female rat is markedly resistant to vitamin K deficiency, the work with chicks suggests that both male and female chicks are equally susceptible to vitamin K deficiency. Bioassay of the chick for vitamin K indicated that there is a difference in content of vitamin K between Labco casein and Nutritional Biochemicals Corporation casein. Rats maintained on Labco casein showed normal prothrombin times, whereas, those on NBC showed elevated prothrombin times. When irradiated and non-irradiated beef, after extraction by alcohol and ether, is fed to male rats, hypopncthrombinemia results. The primary cause of hemorrhagic syndrome in the male rat fed irradiated beef is the destruction of K in beef by irradiation. (auth)
- Research Organization:
- Illinois. Univ., Urbana
- NSA Number:
- NSA-15-005275
- OSTI ID:
- 4092607
- Report Number(s):
- NP-9625
- Country of Publication:
- United States
- Language:
- English
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