ON THE NUTRITIVE VALUE OF THE MAJOR NUTRIENTS OF IRRADIATED FOODS AND APPRAISAL OF THE TOXICITY OF IRRADIATED FOODS. Progress Report No. 17 for Period September 2, 1959-March 15, 1960
Feeding of irradiated beef induces vitamin K deficiency in growing male, but not female, rats. Since the latter seem to require very little dietary vitamin K, even under conditions of coprophagy prevention, susceptibility to K deficiency appears to be a primary sex difference in the rat. Non-coprophagic female rats fed a K-free synthetic diet conceived, but none of the litters born survived beyond three days.Studies on the nature of the hemorrhagic syndrome encountered in weanling male rats fed irradiated beef indicated that the syndrome was caused by a lack of vitamin K and not by any hypoprothrombinemic factor in irradiated beef. This conclusion was based on (1) when the level of irradiated beef in the diet was increased. the incidence and severity of hemorrhages decreased and (2) the vitamin K requirement of coprophagy-prevented rats fed a diet high in irradiated bcef was found to be the same as that reported for similar rats fed a purified diet. Irradiated beef (2.79 or 5.58 megarad) results in loss of vitamin K activity as measured by the chick assay. Nonirradiated beef has 33 gamma K/sub 1//100 g (on a dry basis): irradiation results in a 50% loss of vitamin K activity. Menadione (K/sub 3/) and vitamin K/sub 1/ when fed orally are equally effective in restoring normal plasma prothrombin time of rats fed irradiated beef diets. (auth)
- Research Organization:
- Illinois. Univ., Urbana
- NSA Number:
- NSA-14-024417
- OSTI ID:
- 4154691
- Report Number(s):
- NP-9049
- Country of Publication:
- United States
- Language:
- English
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