ON THE CAUSE OF VITAMIN K DEFICIENCY IN MALE RATS FED IRRADIATED BEEF AND THE PRODUCTION OF VITAMIN K DEFICIENCY USING AN AMINO ACID SYNTHETIC DIET
Vitamin K deficiency, as seen by a hemorrhagic syndrome, developed in rats fed a diet consisting entirely of ground beef irradiated at 2.79 or 5.58 Mrad. Addition of soybean protein and corn oil to the diet prevented the deficiency. Or, addition of 0.1 mu g vitamin K/sub 1//g of dry irradiated beef diet maintained normal plasma prothrombin levels. There was no evidence that irradiation caused the formation of vitamin K antagonists in ground beef. If coprophagy is prevented, deficiency develops more rapidly in rats on the irradiated beef diet. Assay of the vitamin K activity in the diet indicated that after irradiation of ground beef its menadione-equivalent vitamin K activity falls to 14 to 16 mu g/100 g dry wt compared with 35 in nonirradiated beef. It was estimated that the irradiated beef contains approximates one-half of the vitamin K required to maintain a normal prothrombin level. Fecal synthesis of vitamin K was not diminished by feeding the irradiated beef. (H.H.D.)
- Research Organization:
- Univ. of Illinois, Urbana
- NSA Number:
- NSA-17-013939
- OSTI ID:
- 4750193
- Journal Information:
- Journal of Nutrition (U.S.), Journal Name: Journal of Nutrition (U.S.) Vol. Vol: 77; ISSN JONUA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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