BLOOD-MARROW MIXTURES IN IRRADIATED MICE. Effect of Blood Injection on Bone Marrow Transplantation in Lethally Irradiated Mice

Journal Article · Sat Jul 01 04:00:00 EDT 1961 · A.M.A. Arch. Pathol.

OSTI ID:4843062

Goodman, J W; Congdon, C C

Evidence has been presented that a radiosensitive, immunologically competent cell is present in the blood of normal mice. When injected into an irradiated homologous bone marrow-treated mouse, this cell causes or contributes to the death of the recipient. If isologous blcod cells are used, death results from rejection of the grafted homologous marrow. When homologous blood is given, the marrow graft persists until death of the animal from an exaggerated secondary disease syndrome. Results of parent-F/sub 1/ experiments also are consistent with the existence of an immunologically competent cell in the blood, but some do not agree with the usual parent-F/sub 1/ transplantation theories. The effective cell in the peripheral blood is presumed to be the monocyte or large lymphocyte. It may originate in the germinal centers of organized lymphatic tissues, although other sources cannot be completely ruled out. The presence of immunologically active cells from blood contaminating the bone marrow preparations in experiments with large animals may explain some of the difficulties encountered in getting recovery from lethal irradiation in these species, including man. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-15-029008
• OSTI ID: 4843062
• Journal Information: A.M.A. Arch. Pathol., Journal Name: A.M.A. Arch. Pathol. Vol. Vol: 72
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANIMALS
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
IMMUNITY
IRRADIATION
LETHAL DOSE
LYMPH SYSTEM
LYMPHOCYTES
MAN
MICE
RADIOSENSITIVITY
RECOVERY
TISSUES