PREVENTION OF BONE MARROW HETERO-GRAFTING. USE OF ISOLOGOUS THYMUS IN LETHALLY IRRADIATED MICE
Isologous thymus was shown to prevent the therapeutic action of rat bone marrow in lethally irradiated mice. Histologic study of the experiment showed that thymocytelike cells accumulate in the spleen red pulp of the irradiated animals within 24 hours after injection. This was in contrast to the finding that, with spleen injection after irradiation, lymphocytic cells accumulated in the white pulp. In this situation, evidence for the imnaunologic competence of injected thymus cells lies in the transplantation and subsequent rejection of rat bone marrow in experimental mice as opposed to continuation of the transplantationrepopulation process in appropriate control mice. In addition to this there was striking histologic evidence, particularly in the spleen of the host animal, that Ab-forming and plasma cells appeared in large numbers before the rat marrow grait was rejected. After rejection of the transplant, germinal center restitution in the spleen white pulp and lymph nodes was observed. Other isologous tissues, e.g., blood, spleen, lymph nodes, and bone marrow, prevented permanent transplantation of rat bone marrow, as would be expected. Isologous liver, kidney, and heart muscle elso prevented the therapeutic action of rat bone marrow under the circumstances of these experiments. Where hiatologic studies were carried out, Ab-forming and plasma ceIl proliferation in the spleen preceded rejection of the marrow grait. Germinal center regeneration also was noted. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- NSA Number:
- NSA-15-016859
- OSTI ID:
- 4025968
- Journal Information:
- A.M.A. Arch. Pathol., Journal Name: A.M.A. Arch. Pathol. Vol. Vol: 71
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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