THE INFLUENCE OF SUCCINYLSULFATHIAZOLE (SULFASUXIDINE) UPON THE RESPONSE OF CANINE SMALL INTESTINE TO IRRADIATION
Journal Article
·
· Cancer
DOI:https://doi.org/10.1002/1097-0142(199007/08)14:4<862::AID-CNCR2820140424>3.0.CO;2-J·
OSTI ID:4843025
A study was carried out to determine whether the injury attending intense segmental intestinal irradiation could be reduced by diminishing and altering the intestinal bacterial flora. Sulfasuxidine administration for 3 days before and 6 weeks after irradiation of isolated segments of canine ileum with 4000 r significantly reduced the lethality attending the irradiation of 15- cm lengths of ileum and reduced the inflammatory cell infiltration and edema and increased the vascularity of the granulation tissue internally lining the mucosally denuded areas of 5-cm lengths of ileum. Following the rapid complete loss of mucosa attending irradiational injuries of 4000 r, the size of the mucosally denuded area was reduced by exponential longitudinal shortening by the absorption of the irradiated muscle and connective tissue. An almost complete spontaneous anastomosis of proximal and distal nonirradiated intestine was effected 8 months after the irradiation of 5-cm lengths of ileum. The administration of Sulfasuxidine did not influence this rate of absorption. The mechanisms of the obstruction of the irradiated intestines are discussed. (M.C.G.)
- Research Organization:
- Washington Univ. School of Medicine, St. Louis
- NSA Number:
- NSA-15-029075
- OSTI ID:
- 4843025
- Journal Information:
- Cancer, Journal Name: Cancer Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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