Effect of radiation and radioprotection on small intestinal function in canines

Journal Article · Sun Jan 01 04:00:00 EST 1995 · Digestive Diseases and Sciences; (United States)

DOI:https://doi.org/10.1007/BF02063968· OSTI ID:6642478

Herrera, J L; Vigneulle, R M; Gage, T; MacVittie, T J; Nold, J B; Dubois, A

Radiation with doses >7.5 Gy damages the canine intestinal mucosa, and pretreatment with WR2721 reduces this damage. However, the effects of radiation and of WR2721 on in vivo intestinal transport are unclear. Therefore, we determined canine survival, intestinal transport, and mucosal histology following unilateral abdominal irradiation. Isoperistaltic ileostomies were prepared in 23 dogs under general anesthesia and aseptic conditions. After a three-week recovery period, animals were given either placebo or WR2721, 150 mg/kg intravenously, 30 min prior to 10 Gy cobalt-60 abdominal irradiation. Ileal transport and histology were determined in both groups before exposure and one, four, and seven days after irradiation. Seven-day survival was significantly improved by pretreatment with WR2721 (91% vs 33%, P < 0.02). On day 4, both mucosal integrity and net intestinal absorption were significantly better (P < 0.05) after WR2721 than after placebo. Thus, radiation-induced damage to the ileal mucosa is accompanied by a reduction in net ileal absorption of water and electrolytes in vivo. In addition, pretreatment with WR2721 improves animal survival while reducing ileal damage and improving intestinal absorption.

• OSTI ID: 6642478
• Journal Information: Digestive Diseases and Sciences; (United States), Journal Name: Digestive Diseases and Sciences; (United States) Vol. 40:1; ISSN DDSCDJ; ISSN 0163-2116
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DOGS
DRUGS
GASTROINTESTINAL TRACT
HISTOLOGY
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINAL ABSORPTION
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SYNDROME
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SMALL INTESTINE
SORPTION
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOT