RADIATION CHIMAERAS AND PARABIOSIS

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Strahlentherapie (West Germany)

OSTI ID:4842639

Fritz-Niggli, H

X ray chimaeras were composed of x rayed (100-500 r) middle- and late stages of neurula and nonirradiated germs of triton alpestris of the same age. Likewise, embryos were kept in parabiosis. The nonirradiatcd tissues were marked with vital staining. The x ray injury to the embryo is local, and the cell and tissue destruction is due to the preceding direct noxa. The growt of the x rayed tissue goes on. It is not supplanted and replaced by the non-irradiated tissue. The non-irradiated tissues are incapable of redressing the radiogenic lesions of the partner. Nor do ihe injured cells affect the development of the non- irradiated cells which are independent from ihem. In the united exterior metabolism (parabiosis), neither the disturbances of the development of an embryo x rayed at 100 r, nor the lethal effect of irradiation can be avoided. The nonirradiated partner is no protection. The embryo is not only sensitive io x ray because of the division of its cells, but because of its biochemical activity. The x ray injury to the embryo seems to consist in a sublethnal, heredocellular lesion transforming the cells in an irreversible manner. This biochemical somatic mutation is only accessible to an intracellular therapy. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-12-015300
• OSTI ID: 4842639
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 106; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

AGE-- ANIMALS-- BIOCHEMISTRY-- CHIMERAS-- CYTOLOGY-- DISTRIBUTION-- DYES-- EMBRYOS-- LETHAL DOSE-- METABOLISM-- MITOSIS-- PARABIOSIS-- PHYSIOLOGY-- RADIATION DOSES-- RADIATION INJURIES-- RADIATION PROTECTION-- RADIOSENSITIVITY-- REGENERATION-- SURGERY-- TISSUES-- TRITON ALPESTRIS-- X RADIATION
ANIMAL CELLS-- BIOCHEMISTRY-- CHROMOSOMES-- CYTOLOGY-- EMBRYOS-- GENETICS-- MEDICINE-- MUTATIONS-- RADIATION EFFECTS-- RADIATION INJURIES-- THERAPY-- X RADIATION
BIOLOGY AND MEDICINE