Parabiosis intoxication in inbred rat pairs and its modification by x-irradiation

Journal Article · Tue Oct 01 04:00:00 EDT 1963 · Transplantation See Ishoku

DOI:https://doi.org/10.1097/00007890-196301040-00015· OSTI ID:4171604

Binhammer, R T; Must, B G

Parabiosis intoxication and its modification by x irradiation was investigated in inbred rat strains. Development of intoxication was followed by visual inspection and by taking microhematocrits from tail vein blood before parabiosis and on given days after pairing. Parabiotic groups consisted of Buffalo-Lewis, Lewis-LBF/sub 1/ (Lewis x Buffalo F/sub 1/), and Buffalo-LBF/sub 1/ strain combinations. Lewis rats were more prone to develop an early temporary anemia. Intoxication (anemia of one rat and polycythemia of the other) with fatality developed in most Buffalo-Lewis pairs. When LBF/sub 1/ animals were paired with either parent strain, anemia of intoxication was limited to the hybrid. In BuffaloLBF/sub 1/ combinations all hybrid partners became severely anemic and mortality was complete. Total-body x irradiation (500 r) of Buffalo rats immediately before parabiosis with LBF/sub 1/ partners eliminated intoxication and resultant mortality. In pairs in which the hybrid partner was irradiated, anemia-polycythemia was initiated more rapidly and mortality was high. Irradiation of both partners reduced hematocrit changes but did not prolong survival. Intoxication was interpreted as an immune response of the parent against the hybrid; elimination of the syndrome by irradiation of the parent supports this hypothesis.

• Research Organization: Univ. of Cincinnati
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-000117
• OSTI ID: 4171604
• Journal Information: Transplantation See Ishoku, Journal Name: Transplantation See Ishoku Vol. Vol: 1; ISSN ISHTBS1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
ACIDS
ANEMIA
BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BLOOD CIRCULATION
CHEMICAL REACTIONS
CHEMICALS
COMPLEXES
COPPER
CRYSTALS
DECOMPOSITION
DENSITY
DISEASES
DISTRIBUTION
ELECTRIC CONDUCTIVITY
ELECTRONS
FOURIER ANALYSIS
IMMUNITY
LATTICES
LIGHT
MATHEMATICS
MEASURED VALUES
METALS
MOLECULES
NITROGEN COMPOUNDS
OPACITY
OPTICAL SYSTEMS
OSCILLATIONS
PARABIOSIS
POLYCYTHEMIA
PRECIPITATION
QUANTITY RATIO
RADIATION EFFECTS
RATS
RUTHENIUM COMPOUNDS
SOLUTIONS
TOXICITY
VARIATIONS
WATER
X RADIATION