PARABIOTIC INTOXICATION. I. BLOOD VOLUME, TOTAL CIRCULATING RED CELL MASS, AND Fe$sup 59$ UPTAKE

Journal Article · Sun Apr 01 04:00:00 EST 1962 · Transplantation Bull.

OSTI ID:4789872

MacGillivray, M H; Tokuda, S

The hybrid's anemia in parent-F/sub 1/ parabiotic intoxication in mice is accompanied by a reduction in blood volume and total circuIating red cell mass. The parental polycythemia constantly exhibits an increased total circulating red cell mass. Blood volumes are elevated in the 9th and 11th days of parabiosis but not on the 4th. Histologic, hematologic, and Fe/sup 59/ uptake studies indicate increased erythropoiesis in both parabionts. Alterations in the total red cell mass compartments are compatible with the hypothesis of a massive shift of blood between the parabionts. lt is suggested that this shift is brought about by unequal cross-transfusion resuiting from occlusion of the vascular channels returning blood to the hybrid. Mechanically trapped sensitized RBC or the occlusive action of immunologically competent parental cells are two possible immune mechanisms leading to the hematocrit alterations. (auth)

• Research Organization: California Inst. of Tech., Pasadena
• NSA Number: NSA-16-017372
• OSTI ID: 4789872
• Journal Information: Transplantation Bull., Journal Name: Transplantation Bull. Vol. Vol: 29
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANEMIA
BIOLOGY AND MEDICINE
BLOOD
BLOOD CIRCULATION
BLOOD VESSELS
DISEASES
ERYTHROCYTES
GENETICS
IMMUNITY
IRON 59
METABOLISM
MICE
MICROSCOPY
PARABIOSIS
POLYCYTHEMIA
QUANTITY RATIO
TISSUES
TRACER TECHNIQUES
VOLUME