MECHANISM OF THE HEMORRHAGIC PHENOMENON PRODUCED IN MALE RATS BY FEEDING OF IRRADIATED BEEF. Progress Report No. 5, March 15, 1960 to September 15, 1960
Studies of the difference between male and female animals in susceptibility to hypoprothrombinemia and hemorrhage were continued with animals fed irradiated beef diets and extended to include other diets and also the administration of anticoagulant drugs. Sex differences similar to those of animals fed beef diets are demonstrated in rats receiving a commercial stock diet. A considerable difference was found between two commercial diets in terms of the maintenance of normal coagulation factors. Male animals in several age ranges were found to be more sensitive to the effect of large single doses of the anticoagulant warfarin sodium (coumadin) than are females. Pre-treatment with estradiol benzoate improved the prothrombin levels and the survival of male rats receiving the anticoagulant. A greater mortality after coumadin occurred in females pre-treated with androgens. A/sub c/G levels decreased during continued administration of testosterone to females fed stock as well as beef diets. Strain differences in prothrombin were also noted, and estrogenic activity was demonstrated for both menadione and K/sub i/. (P.C.H.)
- Research Organization:
- Medical Coll. of Virginia, Richmond
- NSA Number:
- NSA-15-027294
- OSTI ID:
- 4842183
- Report Number(s):
- NP-10510
- Country of Publication:
- United States
- Language:
- English
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