MECHANISM OF THE HEMORRHAGIC PHENOMENON PRODUCED IN MALE RATS BY FEEDING OF IRRADIATED BEEF. Progress Report No. 4 for Period: September 15, 1959 to March 15, 1960
Further studies were carried out on the susceptibility of female rats to hemorrhage or hypoprothrombinemia associated with irradiated or control beef diets. Female rats again demonstrated only a relative resistance. Susceptibility to hemorrhage or hypoprothrombinemia was greater in groups of animals in which beef feeding was begun prior to maturity than in older females. In contrast, male animals were not found to develop a significant decrease in susceptibility with maturity. As in the male animals previously studied, a higher mortality and lower levels of prothrombin occurred as the quantity of alpha tocopherol administered was increased. Testosterone injected into mature females already receiving irradiated beef diets resulted in a moderate further decrease in prothrombin and a greater mortality. During the 4-week experimental period, testosterone had no effect on prothrombin levels in female animals receiving nonirradiated beef diets, although a few low values occurred in animals given testosterone while being maintained on stock laboratory diets Accelerator globulin levels were lowered by testosterone without regard to the diet being fed. (auth)
- Research Organization:
- Medical Coll. of Virginia, Richmond
- NSA Number:
- NSA-14-025231
- OSTI ID:
- 4143569
- Report Number(s):
- NP-9038
- Country of Publication:
- United States
- Language:
- English
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