THE INFLUENCE OF ADRENALECTOMY ON THE METABOLIC ACTIONS OF GLUCAGON IN THE FASTED RAT

Technical Report · Wed Dec 30 04:00:00 EST 1959

OSTI ID:4842160

Glasser, S R; Izzo, J L; Crump, S L

ABS>The metabolic effects of ddily injections of glucagon during a five- day fast were investigated in adrenalectomized female rats maintained on either saline or hydrocortisone. As in the intact fasting rat, administration of glucagon to the adrenalectomized animal mdintained on saline caused an increased urinary excretion of nitrogen, phosphorus and creatinine; a greater loss in body weight and decreased mass of liver and muscle tissues; and a fall in blood alpha amino nitrogen. However, these changes were lesser in magnitude than the changes observed in the intact fasted rat. In contrast to its effects in the intact rat, administration of glucagon to the adrenalectomized animal maintained on saline did not depress liver glycogen but did elevate blood sugar and muscle glycogen. The metabolic responses to glucagon by adrenalectomized rats maintained on hydrocortisone were similar to those noted in the intact fasted animal. These studies suggest that the protein catabolic sction of glucagon is not dependent on the presence of the adrenal cortex. They further suggest that the effects of glucagon on protein metabolism are an integral part of this hormone's action. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-15-027371
• OSTI ID: 4842160
• Report Number(s): UR-599
• Country of Publication: United States
• Language: English

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
CORTISONE
FASTING
GLANDS
GLUCAGON
GLYCOGEN
HORMONES
LIVER
METABOLISM
NITROGEN
PHOSPHORUS
PROTEINS
QUANTITY RATIO
RATS
SUGARS
SURGERY
URINE