COMPARATIVE EFFECTS OF GLUCAGON, HYDROCORTISONE AND EPINEPHRINE ON THE PROTEIN METABOLISM OF THE FASTING RAT
Technical Report
·
OSTI ID:4150770
An approach toward the elucidation of the mechanism of glucagon in promotirg protein catabolism has been made by comparirg the effects of glucagon and hydrocortisone using female rats fasted five days. The possible relationship of the level of liver glycogen to protein catabolism has also been investigated by comparing the action of glucagon and epinephrine. Both glucagon and hydrocortisonetreated animals lost more weight and excreted more urinary nitrogen, phosphorus, and creatinine than controls. The rate of excretion of glucagon-treated rats declined progressively whereas that of hydrocortisone- treated rats increased progressively throughout the course of the experiment. Although the animals in both groups lost similar amounts of urinary nitrogen the glucagon-treated rats lost less body weight, tissue protein and urinary phosphorus, Furthermore, hydrocortisone caused an elevation in the level of blood alpha -amino nitrogen whereas glucagon caused blood alpha -amino nitrogen to be depressed. These results suggest that glucagon and hydrocortisone cause protein catabolism by different mechanisms. It is proposed that glucagon acts directly on the liver to facilitate the catabolism of amino acids in contrast to the postulated action of hydrocortisone in mobilizing amino acids from extrahepatic tissues. Epinephrine and glucagon depressed liver glycogen but the glycogenolytic effect of epinephrine was of borderline significance, However, epinephrine-treated rats did not differ from controls in respect to any of the above mentioned parameters of protein metabolism. This suggests that the protein catabolic action of glucagon is not directly a consequence of reduced hepatic glycogen. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-14-011410
- OSTI ID:
- 4150770
- Report Number(s):
- UR-564
- Country of Publication:
- United States
- Language:
- English
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