SELECTIVE BETA IRRADIATION OF THE LYMPHATIC SYSTEM USING INTERNALLY ADMINISTERED Y$sup 90$ DTPA: KINETICS, DOSIMETRY, AND BIOLOGICAL EVALUATION (thesis)

Technical Report · Wed Jun 14 04:00:00 EDT 1961

OSTI ID:4840720

Winchell, H S

In order to provide for the relatively selective irradiation of the tissue responsible for the homograft rejection response while minimizing the exposure of other tissues, a technique using internally administered Y/sup 90/ chelated with DTPA (diethylene-triamine-pentaacetic acid) was developed. By use of continuous intravenous recycling of the urine containing the excreted Y/sup 80/ -DTPA a method was developed in which dosimetry is controllable and the excretion of the radioactivity from the body following the cessation of urine recycling is rapid, thereby permitting bone marrow transplantation within 24 hours following the procedure. The clinical, hematologic, and pathologic postirradiation responses of animals receiving Y/sup 90/-DTPA by this method was observed for each group of animals studied. Dogs given sublethal doses of radiation generally had a benign clinical course, the only remarkable finding being a selective lymphopenia without depression of granulocytes, platelets, or reticulocytes. Lethally irradiated dogs showed depression of all formed blood elements but severe depression of lymphocytes was most prominent. Autologous bone marrow is capable of repopulating hematopoietic and lymphopoietic tissues with associated survival of lethally irradiated dogs. Successful homologous bone marrow transplantation apparently was achieved between unrelated beagle dogs. Thus, a new radiation procedure was developed which offers greater selectivity in suppressing the activity of lymphatic structures, and presumably the homograft rejection response. The results suggest the usefulness of this procedure in the treatment of malignancies of lymphatic structures and in the preparation of large mammals for transplantation of homologous tissues. (auth)

• Research Organization: California. Univer., Berkeley. Lawrence Radiation Lab.
• DOE Contract Number: W-7405-ENG-48
• NSA Number: NSA-15-030389
• OSTI ID: 4840720
• Report Number(s): UCRL-9755
• Country of Publication: United States
• Language: English

Related Subjects

BETA DECAY
BIOLOGY AND MEDICINE
BONE MARROW
CHELATES
DOGS
LETHAL DOSE
LEUCOCYTES
LIFETIME
LYMPH SYSTEM
MEASURED VALUES
MEDICINE
QUANTITY RATIO
RADIATION DOSES
TISSUES
TRACER TECHNIQUES
TRANSPLANTS
TUMORS
URINE
YTTRIUM 90