RELATIVELY SELECTIVE BETA IRRADIATION OF LYMPHATIC STRUCTURES IN THE DOG USING Y$sup 90$-DTPA
In an attempt to provide relatively selective irradiation of tissues responsible for the homograft rejection response and to minimize exposure of other radiosensitive tissues, a technique using internally administered /sup 90/Y chelated with diethylenetriaminepentaacetic acid (DTPA) was developed. Dogs given sublethal doses of /sup 90/Y-DTPA radiation had a benign clinical course, the only remarkable finding being a selective lymphopenia without depression of granulocytes, platelets, or reticulocytes. Dogs lethally irradiated with /sup 90/ Y-DTPA showed depression of all formed blood elements, and severe depression of lymphocytes was most prominent. As the homograft rejection response appears to be a function of lymphatic tissues, the results obtained suggest the use of this procedure to prepare large mammals for homologous tissue transplantation. (auth)
- Research Organization:
- Univ. of California, Berkeley
- NSA Number:
- NSA-18-019601
- OSTI ID:
- 4024637
- Journal Information:
- Blood (U.S.), Journal Name: Blood (U.S.) Vol. Vol: 23; ISSN BLOOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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