RELATIVELY SELECTIVE BETA IRRADIATION OF LYMPHATIC STRUCTURES IN THE DOG USING Y$sup 90$-DTPA

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Blood (U.S.)

OSTI ID:4024637

Pollycove, M; Andersen, A C; Lawrence, J H; Winchell, H S

In an attempt to provide relatively selective irradiation of tissues responsible for the homograft rejection response and to minimize exposure of other radiosensitive tissues, a technique using internally administered /sup 90/Y chelated with diethylenetriaminepentaacetic acid (DTPA) was developed. Dogs given sublethal doses of /sup 90/Y-DTPA radiation had a benign clinical course, the only remarkable finding being a selective lymphopenia without depression of granulocytes, platelets, or reticulocytes. Dogs lethally irradiated with /sup 90/ Y-DTPA showed depression of all formed blood elements, and severe depression of lymphocytes was most prominent. As the homograft rejection response appears to be a function of lymphatic tissues, the results obtained suggest the use of this procedure to prepare large mammals for homologous tissue transplantation. (auth)

• Research Organization: Univ. of California, Berkeley
• NSA Number: NSA-18-019601
• OSTI ID: 4024637
• Journal Information: Blood (U.S.), Journal Name: Blood (U.S.) Vol. Vol: 23; ISSN BLOOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETIC ACID
AMINES
ANIMAL CELLS
BETA DECAY
BIOLOGY AND MEDICINE
BLOOD CELLS
CHELATES
DOGS
DTPA
ETHYLENE
IMMUNITY
IRRADIATION
LETHAL DOSE
LYMPHOCYTES
PLATELETS
QUANTITY RATIO
TRANSPLANTS
VARIATIONS
YTTRIUM 90