HISTOPATHOLOGICAL EFFECTS OF X-IRRADIATION OF THE TRANSPLANTED ADRENAL CORTEX ON SHIELDED LYMPHATIC ORGANS IN RATS (thesis)
A study was made of the response of shielded lymphatic tissue to direct x irradiation of the nonmedullated adrenal gland, by transplanting adrenal tissue to the legs of rats, where it would easily be irradiated, free from the radiosensitive tissues of the abdomen and from abdominal nerve tlssues that may mimic the medulla. Methods and materials are described including surgical procedures, animals and animal maintenance, radiatlon, cllnlcal observations, sacrifice schedule, postmortem dissection and examination, tissue preparation, and histelogical examlnations. Doses of 1500 to 2000 r were delivered to the legs. Data indicated that the atrophic effects in the shielded thymus were probably mediated indirectiy through the adrenal cortex, and were not produced through the dlrect effects of irradlatlon of the transplanted adrenal cortex. The atrophic effects in the lymphatic tissue of the shielded spleen were produced largely by direct irradiation of the adrenal cortex rather than by indlrect mediatlon through the adrenal cortex. It was concluded that some of the splenic lymphatic change may be produced indirectiy by some means independent of the adrenal. The adrenal, with the ordinary staining methods used, revealed no destructive cellular changes. (M.C.G.)
- Research Organization:
- Rochester, N.Y. Univ.
- NSA Number:
- NSA-16-018768
- OSTI ID:
- 4840576
- Report Number(s):
- TID-15697
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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