IMMUNOLOGIC STUDY OF ANTIBODY-FORMING CELLS IN MOUSE RADIATION CHIMERAS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Journal of Immunology (U.S.)

OSTI ID:4839363

Doria, G; Goodman, J W; Gengozian, N; Congdon, C C

Twelve-week-old (101 x C3H)F/sub 1/ and (C57BJ/6 x DBA/2)F/sub 1/ mice were used as irradiated recipients or normal adult donors of hematopoietic tissues. Mice of both strains were given a single total-body exposure of 900 r. The ability of the long-term radiation chimeras to produce hemagglutinin (to sheep red cells) was greater in isologous than in homologous combinations. This was found for both fetal liver and bone marrow chimeras. In homologous chimeras, the spleen cells responsible for agglutinin production were of the donor type, regardless of the hematopoietic tissues and strain combinations used. Fetal liver and adult bone marrow contained potential or actual antibody-forming cells which, transplanted into an irradiated host, conferred to it an immune system of the donor type. The immune response of donor cells transplanted from homologous chimera spleens into irradiated recipients was qualitatively normal, but quantitatively subnormal. (H.H.D.)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-16-020273
• OSTI ID: 4839363
• Journal Information: Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 88; ISSN JOIMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
BONE MARROW
ERYTHROCYTES
FETUSES
IMMUNITY
LIVER
MICE
QUANTITY RATIO
RADIATION DOSES
SPLEEN
TISSUES
TRANSPLANTS