INHIBITION OF TRANSPLANTS OF SPONTANEOUS ISOLOGOUS TUMORS IN MOUSE RADIATION CHIMERAS
The effect of lethal (750-r), whole-body x irradiation of C3H mice, followed by restoration with hematopoietic cells, on the growth of subsequently implandted primary or early passage spontaneous C3H carcinomas was investigated. Liver, spleen, and bone marrow served as sources of hematopoietic cells. It was found that irradiated C3H mice protected with hematepoietic cells acquired increased resistance to the growth of grafted C3H tumors. Acquired resistance to isologous tumors was found to be of the same degree irrespective of whether the chimera was of isologous or homologous composition, or whether the restorative donor material was embryonic liver, adult spleen, or adult bone marrow. This acquired tumor insusceptibility was present to the same extent irrespective of whether tumor challenge was performed three weeks or up to eight months after irradiation. Experiments using sublethal irradiation (550-r) of C3H mice and subsequent challenge of the survivors with isologous spontandeous carcinomas demonstrated that irradiation alone could produce a corresponding tumor- inhibiting effect that persisted for a few months. It is concluded that the observed inhibition of growth in radiation chimeras of spontaneous tumors isologous to the recipient is mainly caused by x irradiation per se, since application of a wide variety of donor material results in tumor inhibition of the same order of magnitude, and since a sublethal dose of x rays without cell replacement also results in longlasting resistance to this type of isologous tumor graft. (BBB)
- Research Organization:
- Statens Seruminstitut, Copenhagen
- NSA Number:
- NSA-18-005012
- OSTI ID:
- 4121726
- Journal Information:
- Acta Pathologica et Microbiologica Scandinavica (Denmark) Divided into Acta Pathol. Microbiol. Scand., Sect. A and Acta Pathol. Microbiol. Scand., Sec, Journal Name: Acta Pathologica et Microbiologica Scandinavica (Denmark) Divided into Acta Pathol. Microbiol. Scand., Sect. A and Acta Pathol. Microbiol. Scand., Sec Vol. Vol: 51; ISSN APMIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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