INCREASED LIVER WEIGHT IN BONE MARROW CHIMERAS

Journal Article · Sat Jun 01 04:00:00 EDT 1963 · Exptl. Mol. Pathol.

DOI:https://doi.org/10.1016/0014-4800(63)90042-X· OSTI ID:4640751

Congdon, C C; Kretchmar, A L

Lethally irradiated mice treated with bone marrow develop enlarged livers within two weeks. When donor bone marrow is isologous, the liver returned to a normal wt in about 20 days. However, when donor marrow is homologous, the liver wt was maximal at about two weeks, and the liver remained heavier than in the sham-irradiated, normal controls throughout the 95-day period of observation. The total nitrogen content of tbe liver of homologous, marrow-treated mice was considerably increased during the period of maximal liver enlargement, but normal nitrogen concentration was maintained. Glycogen and lipid content of the liver was normal, but phosphorus concentration in the foreign marrow-treated mice was elevated. Histologic study of the enlarged liver demonstrated individual hypertrophy of liver cord cells. Some extramedullary blood formation was present. During the period of liver enlargement, maximal proliferation of blood-forming cells and antibody-forming tissue in the spleen was observed. Correlation of liver wt with spleen wt was observed at the early intervals in the foreign marrow- injected animals, but was not present at 55 to 95 days. There was always a correlation between liver and spleen wt in isologous marrow-treated mice. This was also true in normal controls. Increased liver wt in the bone marrow chimera may represent a work hypertrophy to provide essential metabolites, such as the purine precursors, for the proliferating cellular systems of the hematopoietic and lymphatic organs. The graft-against-host antibody-forming tissue's cytotoxic action not only destroys the lymphatic organs but also has the effect of a general protoplasmic poison and injures many tissues, including the liver. In destroying the lymphatic tissues, the graft antibody-forming tissue is itself destroyed. This concept provides for a general cytotoxic action to graft-against- host antibody-forming cells, and the final metabolic disturbance and death in secondary disease result from such systemic poisoning. (BBB)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-17-035508
• OSTI ID: 4640751
• Journal Information: Exptl. Mol. Pathol., Journal Name: Exptl. Mol. Pathol. Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIBODIES
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
CYTOLOGY
GLYCOGEN
IMMUNITY
IRRADIATION
LETHAL DOSE
LIPIDS
LIVER
LYMPH SYSTEM
METABOLISM
MICE
NITROGEN
ORGANIC NITROGEN COMPOUNDS
PHOSPHORUS
PURINES
QUANTITY RATIO
SPLEEN
SUGARS
TOXICITY
TRANSPLANTS
WEIGHT