STUDIES ON TRANSFER OF ANTIBODY FORMATION BY ISO AND HETERO-TRANSPLANTS
An in vivo antigen-antibody reaction has been implicated as the cause of secondary or late deaths in lethally irradiated mice treated with genctically foreign bone marrow. Whether the host initiates an immunologm-cal reaction against the foreign graft or vice versa remains to be clarified. Although both mechanisms appear possible, direct immunological evidence in support of either or both mechanisms is still lacking. The injection of spleen cells from immummized rats into lethally irradiated mice resulted in the transfer of antibody synthesis. The antibody formed was shown by scrological means to be rat gamma globulin. Absencc of antibody production was observed following transplantation of bone marrow from the same donors. This is the first successful report of the transfer of antibody formation between donors and recipients of different specics. Studies with isologous cell transfers gave similar findings. Continued and prolonged antibody synthesis was observed upon transfer of spleen cells from immunized mice into normal and irradiated isologous recipients. Transfer of bone marrow from the same immunized donors did not result in the production of measurable amounts of circulating antibodies. The results suggest that a graft vs. host reaction is possible if lymphoid tissues are transplanted. However, support for a similar reaction following transplantation of rat bone marrow was not indicated. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-13-010782
- OSTI ID:
- 4281985
- Report Number(s):
- USNRDL-TR-297
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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