Transplantation of Chimeric Bone Marrow
Journal Article
·
· International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
Retransplantation of bone marrow was studied in an attempt to understand why fetal liver was superior to adult bone marrow in the treatment of lethally- irradiated mice. Presensitization experiments, in which recipients were immunized against cells of the future donor strain, were performed. In this system fetal-liver-chimeric spleen cells were as effective antigenically as those taken from adultbone-marrow chimeras. Fetal-liver-chimeric bone marrow, used to protect irradiated mice that had been presensitized to normal homologous donor- type cells, was as ineffective as that from normal mice of comparable strain. From these results an unaltered sensitivity of the fetallyderived chimeric cells to specific isoantibodies was deduced. The findings are discussed in relation to several postulates offered to explain the ameliorating effect of fetal liver on homologous disease in radiation chimeras. Investigations failed to show a loss of either isoantigenicity or sensitivity to specific antibodies on the part of chimeric cells of fetal origin. The superiority of chimeric cells of fetal origin over those of adult-marrow origin in retransplantation bone-marrow experiments is consistent with a tolerant state of fetally-derived donor cells to the host strain. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-008454
- OSTI ID:
- 4107137
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 1 Vol. 3; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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