THE STATE OF IMMUNITY IN GUINEA-PIGS IMMUNIZED WITH LIVE BRUCELLOSIS VACCINE AND EXPOSED TO RADIATION
Journal Article
·
· J. Microbiol., Epidemiol. Immunobiol. (U.S.S.R.) (English Translation)
OSTI ID:4839021
On immunization with 19-BA live brucellosis vaccine on the 3rd and 10th days after exposure to radiation in a dose of 200 r, guinea pigs died 4 and 2 times more frequently than unvaccinated guinea pigs. If immunization was carried out on the 30th day after irradiation the mortality among irradiated animals showed only a slight increase compared with the mortality among unvaccinated control animals. Immunization carried out before exposure to radiation had no influence upon the mortality of the animals caused by radiation sickness. Guinea pigs immunized after exposure to radiation were insusceptible when infected with the doses of virulent strains of Brucella usually employed to challenge immunity (2-4 infective doses). If, however, the animals were infected with a dose twice as high (8 infective doses) the degree of immunity proved to be lower in guinea pigs exposed to radiation, than in guinea pigs immunized and not exposed to radiation. Exposure of guinea pigs to radiation at a time when immunity had already developed had no influence upon the degree of immunity on infection with 4 infective doses of the virulent strain. (auth)
- Research Organization:
- Gamaleya Inst. of Epidemiology and Microbiology, Academy of Medical Sciences, USSR
- NSA Number:
- NSA-15-032034
- OSTI ID:
- 4839021
- Journal Information:
- J. Microbiol., Epidemiol. Immunobiol. (U.S.S.R.) (English Translation), Journal Name: J. Microbiol., Epidemiol. Immunobiol. (U.S.S.R.) (English Translation) Vol. Vol: 31
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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