THE EFFECT OF SMALL DOSES OF IONIZING RADIATION AND OF CYSTAMINE ON THE MITOTIC ACTIVITY OF CORNEAL EPITHELIUM AND OF DUODENAL CRYPTS

Journal Article · Thu Mar 01 04:00:00 EST 1962 · Doklady Akad. Nauk S.S.S.R.

OSTI ID:4838083

Berlin, L B

White rats (l88 g in weight) were given a total Co/sup 60/ dose of 65 r with and without the administration of 60 mg/kg body weight of the disulfide derivative of mercaptoethylamine. Mitoses were determined on plane sections of the cornea and of the duodenum which are two tissues that differ greatly in radiosensitivity. The normal mitoses are 150 in the summer and 87 in the winter for the cornea, and l08 for the duodenal tissue. The number of mitoses in the corneal tissue drops to 24 one hour after irradiation and then returns to normal within 20 hours after irradiation with a sharp increase in mitotic activity thereafter (149 to 189 dividing cells). The change in the number of mitoses in the duodenal tissue is less pronounced. The introduction of the mercaptoethylamine derivative did not substantially affect the mitotic activity observed in irradiated animals which had not been given a protective chemical compound. (TTT).

• Research Organization: Kirov Military-Medical Academy, USSR
• NSA Number: NSA-16-021940
• OSTI ID: 4838083
• Journal Information: Doklady Akad. Nauk S.S.S.R., Journal Name: Doklady Akad. Nauk S.S.S.R. Vol. Vol: 143
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINES
ANIMAL CELLS
BIOLOGY AND MEDICINE
CHEMICALS
COBALT 60
CYSTAMINE
EYES
GAMMA RADIATION
INTESTINE
MEA
MITOSIS
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION PROTECTION
RATS
THIOLS