THE EFFECT OF NEUTRON IRRADIATION ON THE MITOTIC ACTIVITY OF THE CORNEAL EPITHELIUM (in Russian)
Journal Article
·
· Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)
OSTI ID:4687039
Mice were given whole-body neutron doses of 50, 100, and 200 rads (14% of the dose was gamma -radiation) in a nuclear reactor. The mice were killed on the 1st, 3rd, 5th, and 7th day after irradiation. The number of cells, the size distribution of the cells, the number of mitotic events per 10,000 cells, and the number of chromosomal aberrations (bridges, fragments) during anaphase were determined on stained preparations of the cornea. The average number of cells in the field of view of the microscope at a magnification of 7 x 2.5 x 60 was 203 cells on the average for the controls. The average mitotic index of the cornea was 7.70 x 10/sup -3/ for the controls. Among the observed mitoses, there are on the average 0.386 prophase, 0.234 metaphase, 0.216 anaphase and 0.164 telophase in the controls. The distribution of mitoses in the cornea of the irradiated mice is tabulated according to cell cycle (prophase, metaphase, anaphase, and telophase) for doses of 50, 100, and 200 rads at 1, 3, 6, and 7 days after irradiation. The mitotic activity and the number of cells decrease. A mathematical treatment is used to show that the genetic effect is greatest on the first day after irradiation. The relative biological effectiveness of fast neutrons is 4.6 according to the genetic effect, but is significantly less than 4.6 with respect to the decrease in mitotic activity. It is shown that cells with chromosomal aberrations die at a faster rate than do normal cells. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-030359
- OSTI ID:
- 4687039
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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