ACID DISSOCIATION CONSTANTS AND COMPLEX FORMATION CONSTANTS OF SEVERAL PYRIMIDINE DERIVATIVES

Journal Article · Fri Sep 01 04:00:00 EDT 1961 · Journal of Physical Chemistry (U.S.)

DOI:https://doi.org/10.1021/j100905a024· OSTI ID:4837946

Tucci, E R; Doody, E; Li, N C

Acid disscciation constants of uracil-5-carboxylic acid (isoorotic acid), 2-ethylthio-isoorotic acid, uracil-6carboxylic acid (orotic acid), 5- nitroorotic acid, and adenosine-5' -monophosphate were determined at an ionic strength of 0.1, 25 deg . The formation constants of the Cu(II), Ni(II), Co(II), Zn(II), Mn(II), and Cd(II) complexes of some of these pyrimdine derivatives were determined using pH and ion-exchange methods. The binding sites ih uracil- 5carboxylic acid and 2-ethylthio-isoorotic acid toward metal ions are probably the carboxylate anion and the adjacent oxygen atom. The postulated sites ih 5- nitroorotic acid toward metal ions and uracil-6-carboxylic acid toward Ni ion are the carboxylate and adjacent ring nitrogen anions. The formation constants of the zinc complexes of uracil-5carboxylic acid and 5-nitroorotic acid, and of the sodium and maeganous complexes of adenosihe-5' -monophosphate obtained by the pH method are in agreement with the corresponding values obtaihed by the ion- exchange method, ihdicating that these complexes are mononuclear. (auth)

• Research Organization: Duquesne Univ., Pittsburgh; Christian Brothers Coll., Memphis
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-030672
• OSTI ID: 4837946
• Journal Information: Journal of Physical Chemistry (U.S.), Journal Name: Journal of Physical Chemistry (U.S.) Vol. Vol: 65; ISSN JPCHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDITY
AMMONIUM COMPOUNDS
AMP PROCESS
ANIONS
BINDING ENERGY
CADMIUM
CHEMISTRY
COBALT
COMPLEXES
COPPER
DECOMPOSITION
DRUGS
ETHYL RADICALS
HETEROCYCLICS
ION EXCHANGE
KETONES
MANGANESE
MOLYBDENUM PHOSPHATES
NICKEL
NITROGEN COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OROTIC ACID
PHOSPHATES
PYRIMIDINES
SEPARATION PROCESSES
URACILS
ZINC