Mechanism of the Antibacterial Action of 6-Azauracil-4, 5-$sup 14$C; MEKHANIZM ANTIBAKTERIAL'NOGO DEISTVIYA 6-AZAURATSILA-4, 5-C$sup 1$$sup 4$

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4287796

Skoda, J; Sorm, F

biological reaction was used to prepare relatively large amounts of the carcinostatic 6-azauracil riboside. The formation of 6-azauracil riboside is accompanied by an accumulation in the medium of orotic acid, free uracil, and hypoxanthine. 6-Azauracil is not metabolized in a cell-free extract of E. coli even in the presence of adenosine triphosphate and ribose-5-phosphate. However, the same cell-free extract gives rise to considerable amounts of radioactive nucleotide from 6-azauracil riboside-C/sup 14/ and adenosine triphosphate. The presence of uracil riboside inhibits the formation of 6-azauracil riboside-5'- phosphate. In the absence of adenosine triphosphate not even trace amounts of 6- azauracil riboside-5'-phosphate are formed. (auth)

• Research Organization: Czechoslovakia
• NSA Number: NSA-13-006286
• OSTI ID: 4287796
• Report Number(s): A/CONF.15/P/2124
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADENINE
ATP
BACTERIA
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CARBON 14
DRUGS
ENZYMES
ESCHERICHIA COLI
HETEROCYCLICS
HYPOXANTHINE
KETONES
LABELLED COMPOUNDS
METABOLISM
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OROTIC ACID
PREPARATION
PURINES
PYRIMIDINES
QUANTITY RATIO
RIBOSIDES
URACILS