EFFECTS OF A SINGLE SESSION OF X-IRRADIATION ON PERIPHERAL BLOOD OF RHESUS MONKEY (MACACA MULATTA)
Rhesus monkeys (Macaca mulatta), 11 male and 3 female, aged 6 to 19 years, were used for study on the effects of a single session of x-irradiation (doses 200 r--600 r) on the blood picture. Separated whole-body irradiation (the upper and lower halves of the body irradiated separately) caused more severe injury than whole-body irradiation at one time. The primary cause of death for animals 1 --2 weeks after irradiation was found to be bone marrow aplasia. Counts of erythrocytes, leukocytes made, and the concentration of hemoglobin estimated 2--3 days before death were lower, and the non-filament neutrophils and degenerated leucocytes (which did not show significant change in number after irradiation in survivors) were higher than those of the survivors receiving the same doses of irradiation. These changes may be regarded as prognostic signs for radiation death. Leucocytes, neutrophils, and monocytes rose markedly 6 hours after irradiation and were higher in the lower dose group than in the higher one. This difference may be due to the peak of elevation in the higher dose group taking place prior to 6 hours. The degree of reduction, time of beginning, and completion of recovery of leucocytes, eosinophils, lymphocytes, and monocytes after irradiation bore certain relationships to the size of the doses. The reduction was greater and time for start and completion of recovery longer in the higher dose group than those ib the lower one. Neutrophils with toxic granules, binucleated lymphocytes, and degenerated lymphocytes were also found more frequently in the higher dose group than in the lower one. Neutrophils increased markedly immediately after irradiation to 2--6 times of their preirradiation level, and most of them showed signs of prenecrosis. At the same time non- filament neutrophils rose from their preirradiation level of 2--4% to 5--40% and caused a left shift of the blood picture. Thereafter, neutrophils fell rapidly, and during the first 3 days of reduction, cells with nuclei of 6--10 lobes increased markedly to 2--6 times of their preirradiation level, many of them being giant in size. Hence, a shift to the right of the blood picture was observed a few days after irradiation. Eosinophils, which almost entirely disappeared immediately after ir radiation, returned to normal in 2 days and disappeared again in a few weeks followed by eosinophilia. The small lymphocytes were more radiosensitive than the medium and large ones. The lymphocytes which disappeared after irradiation and reappeared during recovery mostly belonged to the small type. Degenerated lymphocytes increasing to about 0.5--5%, 1--4 days after irradiation, were almost 2--20 times above the normal level. (auth)
- Research Organization:
- Inst. of Biophysics, Academia Sinica, Peking
- NSA Number:
- NSA-15-029056
- OSTI ID:
- 4837833
- Journal Information:
- Sci. Record (Peking) (N.S.), Vol. Vol: 4; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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