CHANGES IN THE PERIPHERAL BLOOD AND BONE MARROW OF RATS AT VARIOUS PERIODS AFTER ADMINISTRATION OF A SINGLE X-RAY DOSE

Journal Article · Sun Aug 21 04:00:00 EDT 1960 · Doklady Akad. Nauk, S.S.S.R.

OSTI ID:4106503

Shmeleva, N I

The leucocyte count and blood formula were determined at 3, 9, 16, 21, 30, 90, l80, 270, and 360 days after the irradiation of rats with a dose of 500 r. At 30 days the per cent and absolute number of segmented neutrophils was twice the initial level, and the per cent of lymphocytes was 68.3%, compared to 81.7% before irradiation. At 90 day's the per cent of polymorphonuclear neutrophils was 1.9%, compared to 0.9% before irradiation, while the per cent of segmented neutrophils increased from 14 to 22.4%. At 180 days a shift to the left was observed in the blood formula. The per cent of polymorphonuclear neutrophils rose to 5.4%. The number of mature neutrophils was twice the initial level. The per cent and absolute number of lymphocytes was significantly lower than in unirradiated rats. At 270 days the number of leucocytes in the irradiated rats exceeded that of the controls by a factor of 1.5. The shift to the left was more pronounced with the number of polymorphonuclear neutrophils exceeding that of the controls by a factor of 5. At this time hyperplasia of the bone marrow occurred (36.3 mg vs. 16 mg for the weight of bone marrow in the control rats). At 360 days a further increase in the weight of the bone marrow and the number of nucleated cells was observed. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-008542
• OSTI ID: 4106503
• Journal Information: Doklady Akad. Nauk, S.S.S.R., Journal Name: Doklady Akad. Nauk, S.S.S.R. Vol. Vol: 133
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
LEUCOCYTES
RADIATION EFFECTS
RATS
X RADIATION