THE EFFECT OF IONIZING RADIATION ON THE REGULARITY OF THE VACCINAL PROCESS FOLLOWING BCG IMMUNIZATION IN EXPERIMENT (in Russian)
BS>The influence of x irradiation upon the regularity of the vaccinal process in guinea pigs inoculated subcutaneously with a single dose of the BCG strain in the amount of 1 to 2 mg was studied. It was found that irradiation of guinea pigs at various stages of the BCG vaccinal process in a smaller dose (100 r) does not change essentially the quality and the dynamics of the process. On the other hand, exposition to penetrating radiation of a higher dose (200 r) does. There was, however, no intensification in the specific reactive tissue structures, which might have testified to any changes of the biological properties peculiar to the introduced vaccinal microbacteria. The isolated BCG cultures also showed no sign indicating their alteration. The adaptation of the BCG in the organism of the irradiated animal pursued the course common to the regular dynamics. Certain distinctions in the degrees of tuberculin reactions were evident. Exposure to a dose of 200 r weakened the animals during the first weeks. Some deaths occurred as a result of hemorrhages in the organs and lymph nodes. (auth)
- Research Organization:
- Gamolei Inst. of Epidemiology and Microbiology, Academy of Sciences, USSR
- NSA Number:
- NSA-16-000062
- OSTI ID:
- 4837182
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Vol. Vol: 6: No. 7; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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