PROLIFERATION AND REJECTION OF TRANSPLANTED TRITIUM LABELED BONE MARROW CELLS IN MICE

Journal Article · Sun Apr 01 04:00:00 EST 1962 · Transplantation Bull.

DOI:https://doi.org/10.1097/00006534-196204000-00039· OSTI ID:4835279

Balner, H; Simmel, E B; Clarke, D A

Tritium-labeled mouse bone marrow cells could be traced radioautographically for as long as 8 days after transplantation into irradiated recipients. Proliferating donor cells were shown to participate in the repopulation of the depleted hemopoietic and lymphatic tissues of the host, but it was difficult to explain initial regeneration exclusively on the basis of colonizing donor cells. Labeled donor cells injected into non-irradiated homologous hosts disappeared by the 4th day, suggesting a rejection time of 3 or 4 days. Rejection time was less than 18 hours if recipients were previously immunized against H-2 antigens of the donor. Rejection of donor cells was delayed if the recipients were injected shortly after birth. Radioautogr-phy is proposed as an accurate method to determine the rejection time of dissociated cells under various conditions. (auth)

• Research Organization: Sloan-Kettering Inst. of Cancer Research, New York
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-017548
• OSTI ID: 4835279
• Journal Information: Transplantation Bull., Journal Name: Transplantation Bull. Vol. Vol: 29
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
CYTOLOGY
IMMUNITY
MICE
RADIOAUTOGRAPHY
REGENERATION
TRACER TECHNIQUES
TRANSPLANTS
TRITIUM