EXPERIMENTAL STUDY OF /cap beta/-RAY RADIATION

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Keio Igaku (Japan)

OSTI ID:4833294

Otsuka, T

Applicators for BETA radiation of P/sup 32/, Sr/sup 89/, Sr/sup 90/, and Y/sup were made and experiments were carried out. From 15-20 mu c of P/sup 32//sq cm and 16.5 mu c of Sr/sup 90//sq cm were absorbed on filter paper; dry vinyl wax was applied and the paper was backed by Pb plate 0.3 mm thick. This was kept in a polyethylene bag and then used clinically as a safe radiation source. Handling of Sr/sup 90/ had to be especially careful. The dose was measured by an extrapolation chamber; 16.5 mu c/sq cm of Sr/sup 90/ was 6 rad/ mu ch, 15 mu c/sq cm of P/sup 32/ was 3.6 rad/ mu ch. The dose of 16.5 mu c/sq cm of Sr/sup 90/ through a paraffin plate (specific gravity = 0.92) was measured by a film density method using Kodak x-ray film. The transit dose was 75% for paper 1 mm thick, 47% for 2 mm, 33% at 3mm, zero at 8 mm. 16.5 mu c/sq cm of Sr/ sup 90/ was applied to the skin surface of the back of guinea pig and the reaction studied inacroscopically and histologically. Macroscopically slight dry dermatitis was seen at 800 mu ch and wet dermatitis at 1200 mu ch. Re- epithelization was seen at about 1 week, when the low dose was applied and at about 3 weeks in high-dose radiation. Histologically, immediately after radiation degeneration of the basal cells and condensation and swelling were seen. In the corium there was edema, swelling of the connective tissues, and leucocyte and lymphocyte infiltration. These changes were slight at 800 mu ch, which reached a maximum at about 1 week, but at associated with erosion or ulceration); after 3 weeks regeneration of epithelial cells was seen. During recovery there was a marked increase in basal cells, connective tissues, and fiber formation. In the guinea pig the dose causing dry and wet dermatitis was 1000-1200 mu ch which was higher than that in humans and recovery was relatively faster than that of human skin. (Abstr. Japan Med., 1: No.

• Research Organization: Keio Univ., Tokyo
• NSA Number: NSA-16-002077
• OSTI ID: 4833294
• Journal Information: Keio Igaku (Japan), Journal Name: Keio Igaku (Japan) Vol. Vol: 36; ISSN KEIGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

HEALTH AND SAFETY